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Introduction of REW into human IgG1, specific for the hapten 4-hydroxy-3-iodo-5-nitropenylacetyl (NIP), did not reduce production rate, as the amounts of secreted protein were equal to that of wild-type (WT) IgG1 in a serum-free Expi293 expression system (Fig

Published 2021-5-11 Type 2 diabetes mellitus (T2DM) is closely associated with cardiovascular diseases (CVD), including atherosclerosis, hypertension and heart failure

Overview of IR The metabolites of chronic overnutrition, such as high glucose and non-esterified fatty acids (NEFAs), interfere with the activation of insulin receptor and its subsequent IRS-1/PI3K/Akt2 pathways, leading to the development of chronic inflammation in adipose tissue and ectopic lipid deposition in the liver and muscles, along with ERS and oxidative stress, etc